Congenital Anomalies among Infants of Diabetic Mothers

is two to five times greater in infants of diabetic mothers than in other infants. Poor glycemic control in the first trimester during organogenesis is thought to be the major reason for congenital malformations (1). The most frequently seen types of malformations in infants of diabetic mothers involve the cardiovascular, skeletal, central nervous, gastrointestinal and genitourinary systems, with cardiac malformations being the most common (2). Four infants who were admitted to the Neonatal Intensive Care Unit (NICU) of our institution are presented here in a discussion of rare congenital malformations in infants of diabetic mother. CASE 1 A 4.0-kg male infant born at 36 weeks to a gestational diabetic mother was admitted to the NICU at the third postnatal day because of poor sucking and jaundice. Physical examination revealed dehydration, jaundice and macrosomia. The infant had hypoglycemia, indirect hyperbilurubinemia, renal failure (prerenal), hyponatremia and metabolic acidosis. Abdominal Doppler ultrasonography revealed situs inversus, and an adrenal hemorrhage was performed. The diagnosis of situs inversus totalis was confirmed with the finding of dextrocardia. The infant was treated for renal failure, hyperbilurubinemia and electrolyte imbalance and was discharged on the twelfth postnatal day. 31 Atasay Beg m, G nlemez Ayla, Arsan Saadet